COVID-19 and ethnicity: A novel pathophysiological role for inflammation.
Identifieur interne : 000359 ( Main/Exploration ); précédent : 000358; suivant : 000360COVID-19 and ethnicity: A novel pathophysiological role for inflammation.
Auteurs : Abhinav Vepa [Royaume-Uni] ; Joseph P. Bae [Royaume-Uni] ; Faheem Ahmed [Royaume-Uni] ; Manish Pareek [Royaume-Uni] ; Kamlesh Khunti [Royaume-Uni]Source :
- Diabetes & metabolic syndrome [ 1878-0334 ] ; 2020.
Abstract
INTRODUCTION
There have been recent mounting concerns regarding multiple reports stating a significantly elevated relative-risk of COVID-19 mortality amongst the Black and Minority Ethnic (BAME) population. An urgent national enquiry investigating the possible reasons for this phenomenon has been issued in the UK. Inflammation is at the forefront of COVID-19 research as disease severity appears to correlate with pro-inflammatory cytokine dysregulation. This narrative review aims to shed light on the novel, pathophysiological role of inflammation in contributing towards the increased COVID-19 mortality risk amongst the BAME population.
METHODS
Searches in PubMed, Medline, Scopus, medRxiv and Google Scholar were performed to identify articles published in English from inception to 18
RESULTS
We suggest a novel pathophysiological mechanism by which acute inflammation from COVID-19 may augment existing chronic inflammation, in order to potentiate a 'cytokine storm' and thus the more severe disease phenotype observed in the BAME population. Obesity, insulin resistance, cardiovascular disease, psychological stress, chronic infections and genetic predispositions are all relevant factors which may be contributing to elevated chronic systemic inflammation amongst the BAME population.
CONCLUSION
Overall, this review provides early insights and directions for ongoing research regarding the pathophysiological mechanisms that may explain the severe COVID-19 disease phenotype observed amongst the BAME population. We suggest 'personalization' of chronic disease management, which can be used with other interventions, in order to tackle this.
DOI: 10.1016/j.dsx.2020.06.056
PubMed: 32640416
PubMed Central: PMC7326443
Affiliations:
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Bae</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medicine, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire</wicri:regionArea><wicri:noRegion>Buckinghamshire</wicri:noRegion></affiliation></author><author><name sortKey="Ahmed, Faheem" sort="Ahmed, Faheem" uniqKey="Ahmed F" first="Faheem" last="Ahmed">Faheem Ahmed</name><affiliation wicri:level="3"><nlm:affiliation>NHS England, Skipton House, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS England, Skipton House, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pareek, Manish" sort="Pareek, Manish" uniqKey="Pareek M" first="Manish" last="Pareek">Manish Pareek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Sciences, University of Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Respiratory Sciences, University of Leicester</wicri:regionArea><wicri:noRegion>University of Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Khunti, Kamlesh" sort="Khunti, Kamlesh" uniqKey="Khunti K" first="Kamlesh" last="Khunti">Kamlesh Khunti</name><affiliation wicri:level="1"><nlm:affiliation>Diabetes Research Centre, University of Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Diabetes Research Centre, University of Leicester</wicri:regionArea><wicri:noRegion>University of Leicester</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32640416</idno><idno type="pmid">32640416</idno><idno type="doi">10.1016/j.dsx.2020.06.056</idno><idno type="pmc">PMC7326443</idno><idno type="wicri:Area/Main/Corpus">000064</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000064</idno><idno type="wicri:Area/Main/Curation">000064</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000064</idno><idno type="wicri:Area/Main/Exploration">000064</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">COVID-19 and ethnicity: A novel pathophysiological role for inflammation.</title><author><name sortKey="Vepa, Abhinav" sort="Vepa, Abhinav" uniqKey="Vepa A" first="Abhinav" last="Vepa">Abhinav Vepa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire, UK. Electronic address: Vepa.Abhinav@nhs.net.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medicine, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire</wicri:regionArea><wicri:noRegion>Buckinghamshire</wicri:noRegion></affiliation></author><author><name sortKey="Bae, Joseph P" sort="Bae, Joseph P" uniqKey="Bae J" first="Joseph P" last="Bae">Joseph P. Bae</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medicine, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire</wicri:regionArea><wicri:noRegion>Buckinghamshire</wicri:noRegion></affiliation></author><author><name sortKey="Ahmed, Faheem" sort="Ahmed, Faheem" uniqKey="Ahmed F" first="Faheem" last="Ahmed">Faheem Ahmed</name><affiliation wicri:level="3"><nlm:affiliation>NHS England, Skipton House, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NHS England, Skipton House, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pareek, Manish" sort="Pareek, Manish" uniqKey="Pareek M" first="Manish" last="Pareek">Manish Pareek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory Sciences, University of Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Respiratory Sciences, University of Leicester</wicri:regionArea><wicri:noRegion>University of Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Khunti, Kamlesh" sort="Khunti, Kamlesh" uniqKey="Khunti K" first="Kamlesh" last="Khunti">Kamlesh Khunti</name><affiliation wicri:level="1"><nlm:affiliation>Diabetes Research Centre, University of Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Diabetes Research Centre, University of Leicester</wicri:regionArea><wicri:noRegion>University of Leicester</wicri:noRegion></affiliation></author></analytic><series><title level="j">Diabetes & metabolic syndrome</title><idno type="eISSN">1878-0334</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>There have been recent mounting concerns regarding multiple reports stating a significantly elevated relative-risk of COVID-19 mortality amongst the Black and Minority Ethnic (BAME) population. An urgent national enquiry investigating the possible reasons for this phenomenon has been issued in the UK. Inflammation is at the forefront of COVID-19 research as disease severity appears to correlate with pro-inflammatory cytokine dysregulation. This narrative review aims to shed light on the novel, pathophysiological role of inflammation in contributing towards the increased COVID-19 mortality risk amongst the BAME population.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Searches in PubMed, Medline, Scopus, medRxiv and Google Scholar were performed to identify articles published in English from inception to 18</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>We suggest a novel pathophysiological mechanism by which acute inflammation from COVID-19 may augment existing chronic inflammation, in order to potentiate a 'cytokine storm' and thus the more severe disease phenotype observed in the BAME population. Obesity, insulin resistance, cardiovascular disease, psychological stress, chronic infections and genetic predispositions are all relevant factors which may be contributing to elevated chronic systemic inflammation amongst the BAME population.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Overall, this review provides early insights and directions for ongoing research regarding the pathophysiological mechanisms that may explain the severe COVID-19 disease phenotype observed amongst the BAME population. We suggest 'personalization' of chronic disease management, which can be used with other interventions, in order to tackle this.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32640416</PMID><DateRevised><Year>2020</Year><Month>07</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-0334</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>5</Issue><PubDate><Year>2020</Year><Month>Jun</Month><Day>30</Day></PubDate></JournalIssue><Title>Diabetes & metabolic syndrome</Title><ISOAbbreviation>Diabetes Metab Syndr</ISOAbbreviation></Journal><ArticleTitle>COVID-19 and ethnicity: A novel pathophysiological role for inflammation.</ArticleTitle><Pagination><MedlinePgn>1043-1051</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1871-4021(20)30225-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.dsx.2020.06.056</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">There have been recent mounting concerns regarding multiple reports stating a significantly elevated relative-risk of COVID-19 mortality amongst the Black and Minority Ethnic (BAME) population. An urgent national enquiry investigating the possible reasons for this phenomenon has been issued in the UK. Inflammation is at the forefront of COVID-19 research as disease severity appears to correlate with pro-inflammatory cytokine dysregulation. This narrative review aims to shed light on the novel, pathophysiological role of inflammation in contributing towards the increased COVID-19 mortality risk amongst the BAME population.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Searches in PubMed, Medline, Scopus, medRxiv and Google Scholar were performed to identify articles published in English from inception to 18<sup>th</sup> June 2020. These databases were searched using keywords including: 'COVID-19' or 'Black and Minority Ethnic' or 'Inflammation'. A narrative review was synthesized using these included articles.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We suggest a novel pathophysiological mechanism by which acute inflammation from COVID-19 may augment existing chronic inflammation, in order to potentiate a 'cytokine storm' and thus the more severe disease phenotype observed in the BAME population. Obesity, insulin resistance, cardiovascular disease, psychological stress, chronic infections and genetic predispositions are all relevant factors which may be contributing to elevated chronic systemic inflammation amongst the BAME population.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Overall, this review provides early insights and directions for ongoing research regarding the pathophysiological mechanisms that may explain the severe COVID-19 disease phenotype observed amongst the BAME population. We suggest 'personalization' of chronic disease management, which can be used with other interventions, in order to tackle this.</AbstractText><CopyrightInformation>Copyright © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vepa</LastName><ForeName>Abhinav</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire, UK. Electronic address: Vepa.Abhinav@nhs.net.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bae</LastName><ForeName>Joseph P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Medicine, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahmed</LastName><ForeName>Faheem</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>NHS England, Skipton House, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pareek</LastName><ForeName>Manish</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Respiratory Sciences, University of Leicester, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khunti</LastName><ForeName>Kamlesh</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Diabetes Research Centre, University of Leicester, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Diabetes Metab Syndr</MedlineTA><NlmUniqueID>101462250</NlmUniqueID><ISSNLinking>1871-4021</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">BAME</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Cardiovascular risk</Keyword><Keyword MajorTopicYN="N">Cytokine storm</Keyword><Keyword MajorTopicYN="N">Ethnicity</Keyword><Keyword MajorTopicYN="N">Inflammation</Keyword><Keyword MajorTopicYN="N">Insulin resistance</Keyword><Keyword MajorTopicYN="N">Metabolic syndrome</Keyword><Keyword MajorTopicYN="N">Obesity</Keyword><Keyword MajorTopicYN="N">Psychological stress</Keyword><Keyword MajorTopicYN="N">SARS CoV-2</Keyword><Keyword MajorTopicYN="N">Type 2 diabetes mellitus</Keyword><Keyword MajorTopicYN="N">Visceral fat</Keyword></KeywordList><CoiStatement>Declaration of competing interest There are no relevant conflicts of interest to declare.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32640416</ArticleId><ArticleId IdType="pii">S1871-4021(20)30225-3</ArticleId><ArticleId IdType="doi">10.1016/j.dsx.2020.06.056</ArticleId><ArticleId IdType="pmc">PMC7326443</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Vepa, Abhinav" sort="Vepa, Abhinav" uniqKey="Vepa A" first="Abhinav" last="Vepa">Abhinav Vepa</name></noRegion><name sortKey="Ahmed, Faheem" sort="Ahmed, Faheem" uniqKey="Ahmed F" first="Faheem" last="Ahmed">Faheem Ahmed</name><name sortKey="Bae, Joseph P" sort="Bae, Joseph P" uniqKey="Bae J" first="Joseph P" last="Bae">Joseph P. Bae</name><name sortKey="Khunti, Kamlesh" sort="Khunti, Kamlesh" uniqKey="Khunti K" first="Kamlesh" last="Khunti">Kamlesh Khunti</name><name sortKey="Pareek, Manish" sort="Pareek, Manish" uniqKey="Pareek M" first="Manish" last="Pareek">Manish Pareek</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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